Dear friends,
On November 10, at 7PM (CET) the young researchers of the FEBS Junior Sections organized their eleventh online talk of 2022. This one is coordinated by the SIB Sezione Giovani, the Junior Section of the Italian Society of Biochemistry and Molecular Biology (SIB).
It will be an academic talk from Prof. Federico Forneris, at the Armenise-Harvard Laboratory of Structural Biology, University of Pavia, Italy, titled “The molecular diversity of collagen lysine post-translational modification enzymes”.

For more information:
https://network.febs.org/posts/sib-sezione-giovani-febs-junior-sections-present-federico-forneris

To register for the talk:
https://us06web.zoom.us/meeting/register/tZMvduuqrTMvHtM1EPNmfcBTU5hrccpnFwXA

Talk abstract:
Collagen lysine residues are subject to a variety of post-translational modifications (PTM) that impact on the overall organization of mature collagens and confer to these complex macromolecules their unique physico-chemical properties. In humans, the PTM machinery acting on collagen lysines groups multifunctional lysyl hydroxylases-glucosyltransferases (LH), galactosyltransferases (GLT25D), lysyl oxidases (LOX) and glucosidases (PGGHG). Besides their fundamental roles in collagen homeostasis, malfunctions in these molecular machineries due to misfolding, mislocalization or abnormal enzymatic activity have been associated to a wide variety of connective tissue diseases as well as increased metastatic progression of numerous solid tumors. By focusing on lysine hydroxylation and subsequent glycosylation events, in our group we have characterized the different human collagen lysyl hydroxylases-glucosyltransferases isoforms and also the galactosyltransferase GLT25D1 using a combination of biochemistry, structural biology and biophysical approaches. Collectively, our published and unpublished results reveal unexpected quaternary organizations that underpin the molecular complexity of these essential, yet poorly characterized molecular systems, providing insights on their cooperative mechanisms of lysine PTM and templates for structure-based drug discovery campaigns.

Please join us at the talk and share this information with your peers. If you want to find out more about the FEBS Junior Sections, visit this page: https://network.febs.org/posts/room-for-junior-sections-of-febs-societies

Thank you and best wishes,

The FEBS Junior Sections